Tales from the transcriptome: discoveries of RNA-editing from RNA-sequencing

Date: 
Wednesday, November 2, 2011 - 16:30
Location: 
TH 331
Presenter: 
Melanie Huntley, PhD (Genentech)
Abstract: 
Believe the central dogma of molecular biology? Think again. Next-generation sequencing of the transcriptome reveals an abundance of transcripts that are edited to be different from their genomic sequence. These edited transcripts result in a cascade of functional consequences: some are essential for survival, while others are incredibly detrimental. Come learn about this fascinating biology and the computational approaches we implement to further our investigations in RNA-editing.
Bio: 

Melanie is a computational biologist in the Bioinformatics & Computational Biology Department at Genentech, Inc. Trained in molecular evolution and genetics at McMaster University in Canada, and Cornell University in NY, she has been a computational scientist throughout her career. She has a passion for genome biology, evolution and development, and thoroughly enjoys the opportunity to share her research stories with audiences.