MT-08.04

Title: 

An Automated Approach for Chromosome Territory Simulation

Author(s): 

Lawrence Rocco Varela

Oral Defence Date: 

06/13/2008

Location: 

SCI 241

Committee: 

Professors Petkovic, Arsuaga, and Okada

Abstract: 

The goal of our research is focused on understanding the geometry and topology of overlapping chromosome regions during the G0/G1 period of the Interphase portion of the cell cycle. We are investigating chromosome behavior by developing a model using a computational approach named the Generalized Hedgehog method. Our simulated models investigate an array of knotting and linking behaviors exhibited by freely-jointed chains which in turn will yield insights of chromosome behavior during the G0/G1 phase of the cell cycle. We used the Generalized Hedgehog method for creating our simulated models in order to formulate justified conclusions about the knotting and linking behavior of chromosomes during the G0/G1 phases of the cell cycle. Analysis of chromosome arrangements and developing a biologically sound computational model will enhance our understanding and investigation techniques of the formation of chromosome aberrations in cancer and radiation exposed cells.

Keywords: 

Polymer modeling, Knot theory, Physics-based simulations, Generalized Hedgehog algorithm, Parallel programming

Copyright: 

Lawrence Rocco Varela