Pharmacogenomics (PGx) and Precision Medicine are young, but rapidly evolving fields that are heralding development of tailored drugs. Knowing the impact of genetic variations on drug response, and other relevant information about the gene (structure, expression, function of its protein, interactions with other genes, drugs, and diseases) is invaluable to PGx researchers and practitioners. The VIP Summaries generated by PharmGKB curators provide exactly that for genes that have been identified as Very Important Pharmacogenes.
In the present world, social networks such as Twitter have become an important medium for the diffusion of information. Quantifying the connection between the users will help us understand the propagation of the knowledge. With this motivation, we focus on designing and implementing a host of reliable measurements to measure the similarity between two users on the Twitter microblogging platform. These measurements take into account both a user’s topical interests and her social connections.